玛蒂娜·布雷默
教授
统计数据, Biostatistics
408-924-1396
玛蒂娜.bremer@volamdolong.com
MH 318
研究领域
- 统计数据
- 生物信息学
传记
I am a statistician with an interest in bioinformatics. In particular, I am interested in the analysis and interpretation of microarray data. DNA Microarrays (or gene chips) exist for many organisms - animals, plants, and humans. They are used to measure the extent to which many genes (humans have about 30,000 protein coding genes) are “turned on” at any given time. Researchers are interested in measuring gene expression to study which genes are associated with a particular condition such as cancer.
Genes are influenced by many things: external factors that an organism is subjected (e.g., drought for plants or disease for humans) but genes and proteins also influence each other in a complicated network. Is it possible to identify genes that are up or down regulated by other genes or by proteins in time course microarray data? 这 question is investigated using a state space model for gene regulation in my 论文(pdf).
出版物
- Harsh Bhatia, Attila G. Gyulassy, Valerio Pascucci, 玛蒂娜·布雷默, Mitchell T. Ong Vincenzo Lordi, Erik W. 约翰·德尔格. Pask, and Peer-Timo 布雷默. Interactive Exploration of Atomic Trajectories Through Relative-Angle Distribution and Associated Uncertainties [pdf]. In Proceedings of the 9th IEEE Pacific Visualization Symposium, pp. 120 - 127,台北, 台湾. 4月. 19–22, 2016.
- M. 布雷默,R.W. Doerge, Using R at the Bench - Step-by-Step Data Analytics for Biologists, Cold Spring Harbor Press, 2015.
- T. 阮,D. Ravindra B. 邝,年代. 他,N. Tarlton R. 弗格森,米. 布雷默,T. 艾布拉姆森, Differential expression of alpha 4 integrins on effector memory cells during Bordetella 感染. Delayed responses in B. 百日咳. PLOS One, December 2012, Vol 7, Issue 12.
- S. Yadegarnynia,. 范教授,. Ng,维. 阮T. Lialiutska,. Bortolazzo V. Syvriuk, M. 布雷默,J.B. 白色， Profiling Flavonoid Cytotoxicity in Human Breast Cancer Cell Lines: Determination of Structure-Function Relationships. Natural Product Communications, 7 (10), 2012.
- N.J. Tarlton C.M. 绿色,N.H. 拉撒路,我. Rott,.P. 阿黄,.N. 艾布拉姆森,M. 布雷默, E.C. 屠夫,T. 艾布拉姆森, Plasmablast frequency and trafficking receptor expression are altered in pediatric 溃疡性结肠炎. Inflammatory Bowel Diseases2012年4月5日.
- J. 公园,P.L. Knezevich W. Wung,年代.N. 欧汉龙,. Goyal K.L. B的说法,.J. Barsi-Rhyne, M. 拉曼,N. 模拟,M. 布雷默,M.K. VanHoeven, A conserved juxtacrine signal regulates synaptic partner recognition in Caenorhabditis 线虫, Neural Development, 6:28, 2011.
- A.Madlung, M. 布雷默,E. Himelblau,. Tullis, A Study Assessing the Potential of Negative Effects in Interdisciplinary Math-Biology 教育, CBE - Life 科学s 教育, Vol 10, 43 - 54, Spring 2011.
- M. 布雷默 & R.W. Doerge, 统计数据 at the Bench: A Step-by-Step Handbook for Biologists, Cold Spring Harbor Press, 2010
- M. 布雷默,E. Himelblau,. Madlung, Introduction to the Statistical Analysis of Two-Color Microarray Data (book chapter) in Bang, H, Zhou, XK, Van Epps, H, Mazumdar, M. (Editors) Statistical Methods in Molecular Biology. 胡玛纳出版社. 2010.
- M. 布雷默 & R.W. Doerge, The KM-Algorithm identifies regulated genes in time series expression data, Advances in 生物信息学, 2009
